Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) is a non-steroidal anti-inflammatory drug (NSAID) belonging to the fenamate group. Tolfenamic acid exerts anti-inflammatory, analgesic and antipyretic activities. The anti-inflammatory activity of Tolfenamic acid is mainly due to an inhibition of cyclo-oxygenase and thus to a reduction in the synthesis of prostaglandins and thromboxanes, which are important inflammatory mediators.
Indications
An anti-inflammatory, antipyretic and analgesic agent indicated:-
Cattle:
As an adjunct in the treatment of acute mastitis, used in conjunction with antibacterial therapy
As an aid in the control of acute inflammation associated with bacterial respiratory disease, used in conjunction with antibacterial therapy.
Pigs:
As an adjunct in the treatment of Metritis, Mastitis, Agalactia syndrome, used in conjunction with antibacterial therapy
Target species
Cattle & Pig
Dosage & Administration
Cattle:
For use in bovine mastitis:
1 ml Tolfimate / 10kg body weight as a single IV injection.
For use in bovine respiratory disease:
1 ml Tolfimate / 20kg body weight by IV or SC injection.
Treatment may be repeated once after 48 hours. If a second injection is needed this should be given in the opposite side of the animal’s body.
Pigs:
1 ml Tolfimate /20kg body weight as a single intramuscular injection, in the neck musculature
Warnings & Precautions
Do not exceed 20ml per intramuscular injection site.
Do not exceed the stated dose or the duration of treatment
Do not administer other NSAIDs concurrently or within 24 hours of each other
Avoid use in any dehydrated, hypovolaemic or hypotensive animal as there is a potential risk of increased renal toxicity.
Do not use in newborn domestic animals
Contra Indications
Not for IM administration in cattle.
Not for IV or SC administration in pigs.
Not for SC administration in dairy cows
Use is contra-indicated in animals suffering from cardiac, hepatic or renal disease.
Where there is the possibility of gastro-intestinal ulceration or bleeding.
Where there is evidence of hypersensitivity to the product.
Side Effects
Transient swelling and inflammation can occur at the injection site.
Withdrawal time
Pigs:
Meat: 3 days
Cattle:
Meat: Following I/V inj. : 3 days
Meat: Following S/C inj. : 7 days
Milk: 24 hours
Storage condition
Store at temperature not exceeding 30°C and valid to 35 days after opening under storage temperature not exceeding 30°C
Packaging
Glass vials : 10, 20 , 30, 50, 100, 250 ml & 500 ml
