FLUNIDYNE
Composition
Each 1 ml contains:
Flunixin meglumine 83 mg
Equivalent to flunixin 50 mg
Properties
Flunixin meglumine is a relatively potent non-narcotic, non-steroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties.
Flunixin meglumine acts as a reversible inhibitor of cyclo-oxygenase, an important enzyme in the arachidonic acid cascade pathway which is responsible for converting arachidonic acid to cyclic endoperoxides. Consequently, synthesis of eicosanoids, important mediators of the inflammatory process involved in central pyresis, pain perception and tissue inflammation, is inhibited. Through its effects on the arachidonic acid cascade, flunixin also inhibits the production of thromboxane, a potent platelet pro-aggregator and vasoconstrictor which is released during blood clotting. Flunixin exerts its antipyretic effect by inhibiting prostaglandin E2 synthesis in the hypothalamus. By inhibiting the arachidonic acid cascade pathway, flunixin also produces an anti-endotoxic effect by suppressing eicosanoid formation and therefore preventing their involvement in anti-endotoxin associated disease states
Indications
Flunidyne Injection is indicated for use in cattle and horses in the alleviation of inflammation and pain.
In the horse, Flunidyne Injection is indicated for the alleviation of inflammatory signs associated with musculo-skeletal disorders and for the alleviation of visceral pain associated with colic.
In cattle, Flunidyne Injection is indicated for the control of acute inflammation associated with respiratory disease.
Flunidyne Injection has also been shown to have some benefit in the treatment of acute pulmonary emphysema [fog fever] and as adjunctive therapy in the treatment of acute mastitis.
In pigs, Flunidyne Injection is indicated as an adjunctive therapy in the treatment of swine respiratory diseases
Target species
Cattle, horses and pigs
Dosage instructions
Flunidyne Injection is indicated for I/V administration to cattle and horses and I/M injection to pigs.
Horses:
For use in equine colic, the recommended dose rate is: 1 ml Flunidyne Injection per 45 kg bodyweight. Treatment may be repeated once or twice if colic recurs.
For use in musculo-skeletal disorders, the recommended dose rate is: 1 ml Flunidyne Injection per 45 kg bodyweight, once daily for up to 5 days according to clinical response.
Cattle:
For use in acute inflammatory conditions, the recommended dose rate is: 2 ml Flunidyne Injection per 45 kg bodyweight. Repeat as necessary at 24 hour intervals for up to 5 consecutive days.
Pigs:
For use in pigs, the recommended dose rate is : 2 ml Flunidyne Injection per 45 kg bodyweight once by intramuscular injection.
Flunidyne Injection should be administered as adjunctive therapy in conjunction with a suitable course of antibacterial therapy
Warnings & Precautions
Avoid intra-arterial injection.
The cause of the underlying inflammatory condition or colic should be determined and treated with appropriate concomitant therapy.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other
Contra Indications
Do not exceed the recommended dose or duration of treatment.
Do not administer to pregnant mares.
Use is contra-indicated in animals suffering from cardiac, hepatic or renal disease.
Where there is the possibility of gastro-intestinal ulceration or bleeding.
Where there is evidence of hypersensitivity to the product.
Side Effects
For this class of drug, untoward effects include gastrointestinal irritation, ulceration and, in dehydrated or hypovolaemic animals, potential for renal damage.
There are occasional reports of collapse following rapid intravenous injection in horses and calves
Withdrawal time
Meat :
Horses and cattle:7 days. Pigs: 24 days.
Milk :
36 hours.
Storage condition
Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30°C
Packaging
Glass vials :10, 30, 50, 100, 200, 250 & 500 ml
