ALBENDAZOLE 2.5%
Composition
Each 100 ml contains:
Albendazole 2.5 gm
Properties
Albendazole is a broad spectrum multi-purpose anthelmintic for the control of mature and developing immature forms of gastrointestinal roundworms, lungworms, tapeworms and adult liver fluke in cattle and sheep. The product is also ovicidal against fluke and roundworm eggs.
Benzimidazoles bind to nematode tubulin, a protein necessary for the formation and viability of microtubules. This occurs primarily in absorptive intestinal cells resulting in the absence of microtubules in the intestinal cells of the nematode, with the result that these cells cannot absorb nutrients, thus causing a consequent reduction in glycogen and effective starvation of the parasites. Structural differences have been shown to exist between tubulin from mammalian and helminth sources, resulting in the preferential toxicity of albendazole to the helminth and not to the host. Benzimidazoles have also been shown to inhibit the fumarate reductase system of helminthes and impair energy production.
Indications
A broad spectrum multi-purpose anthelmintic for the control of mature and developing immature forms of gastrointestinal roundworms, lungworms, tapeworms and adult liver fluke in cattle and sheep. The product is also ovicidal against fluke and roundworm eggs.
In cattle it is active against the following species:
Roundworms: Ostertagia, Haemonchus, Trichostrongylus, Nematodirus, Oesophagostomum, Bunostomum, Cooperia, and Strongyloides spp. It is usually effective against inhibited larvae of Cooperia and Ostertagia,
Lungworms: Dictyocaulus viviparus,
Tapeworms: Moniezia spp.,
Adult liver fluke: Fasciola hepatica.
In sheep it is active against benzimidazole- susceptible strains of the following species:
Roundworms: Ostertagia, Haemonchus, Trichostrongylus, Nematodirus (including N. Battus), Chabertia and Oesophagostomum. It is usually effective against inhibited larvae of Ostertagia,
Lungworms: Dictyocaulus filaria,
Tapeworms: Moniezia spp.,
Adult liver fluke: Fasciola hepatica.
The product is ovicidal and will kill fluke and roundworm eggs, thus reducing pasture contamination.
Target species
Cattle and sheep
Dosage and Administration
For whole product : For oral administration.
Cattle:
Worm dose: For the control of roundworms, lungworms, tapeworms and fluke and roundworm eggs.
Dosage: 3 ml Albendazole 2.5% / 10 kg body weight single oral dose
Fluke and worm dose: For the additional treatment of adult liver fluke (chronic fascioliasis) in cattle:
Dosage: 4 ml Albendazole 2.5% / 10 kg body weight single oral dose and dose should be repeated after 5 to 6 weeks
Sheep:
Worm dose: For the control of roundworms, lungworms, tapeworms, fluke and roundworm eggs.
Dosage: 2 ml Albendazole 2.5% / 10 kg body weight single oral dose
Fluke and worm dose: For the additional treatment of adult liver fluke (chronic fascioliasis) in sheep.
Dosage: 3 ml Albendazole 2.5% / 10 kg body weight single oral dose and dose should be repeated after 5 to 6 weeks
Warnings & Precautions
Do not dose ewes at the ‘fluke and worm’ dose rate, (7.5 mg/kg), during tupping or for 1 month after removing the rams.
Not for use in sheep producing milk for human consumption.
Cattle suffering from severe lung damage due to heavy lungworm infestation may continue to cough for some weeks after infection.
Contra Indications
Do not use in cases of known hypersensitivity to the active ingredient
Side Effects
None known
Withdrawal time
Cattle:
Meat & Offal: 14 days
Milk: 60 hours
Sheep:
Meat & Offal: 5 days
Not to be used in sheep producing milk for human consumption
Storage condition
Store at temperature not exceeding 30°C and used after opening for 35 days at temperature not exceeding 30°C
Packaging
Opaque (HDPE) plastic bottle containing 50, 100, 125, 250, 500 ml, 1, 5, 10 L oral suspension sealed with aluminum seal and capped with (HDPE) plastic cap with outer label containing data.
